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2022 | September / October 2022

API manufacturing and environmental sustainability

by cyb2025
G. Malhotra

GIRISH MALHOTRA
EPCOT International, Pepper Pike, OH, USA

ABSTRACT

Physical properties of chemicals are their unique hallmark. They are used in various unit operations to create simple and excellent chemical processes. They have been used for the last 100+ years to produce different fine/specialty chemicals that have improved our health and life style. Large amount of solvents have allowed use of available equipment to produce different fine/specialty chemicals. Even though most of the solvents are recovered and recycled, they still leave a large environmental footprint. For pharmaceutical active ingredients the foot print is the highest. Creative and thoughtful use of physical properties and unit operations can lead to significant lowering of emissions i.e. towards “Net Zero”. Out the box effort is needed and is reviewed in the book (2).

Pharmaceutical industry’s evolution and history are fascinating (1, 2). Volumes can be written on how the industry and each company has shaped itself. Their evolution is a story. Discussion here is not about the companies but about the development of small molecule active pharmaceutical ingredients (API) (3), their manufacturing methods and environmental impact and how it can be minimized.

ABOUT THE AUTHOR

Girish Malhotra, President and founder of EPCOT International has 55+ years of industrial experience in pharmaceuticals, specialty, custom, fine chemicals, coatings, resins and polymers, additives in manufacturing, process and technology development and business development. He enhances profitability by simplifying technology and manufacturing practices. He has over 300 publications and presentations. He can be reached at girish@epcotint.com

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