YMC – Improved Oligo and Peptide Purification using next generation LC-phases

Molecules of the future with high demands on purity
Therapeutic oligonucleotides and peptides are biopolymers with enormous potential. The reliable and safe production of these molecules is a challenging task because of the impurity profile and the high demands on purity and structural integrity.

For the purification of these types of molecules, (ion-pair-) reversed phase (RP) chromatography is a powerful technique that allows high purity levels with increased productivity. With this technique, efficient separation of small chemical and structural variants is possible – e.g. the separation of single nucleotide differences in oligonucleotides. For a robust and productive purification process, innovative, robust and reproducible stationary phases are needed. The selection of the most appropriate RP phase is the crucial factor in method development as it determines the overall productivity of the final process.