2022 | May / June 2022

Pacritinib

by cyb2025

RODRIGO SOUZA
Biocatalysis and Organic Synthesis Group, Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazils

The third molecule which we are going to present here at “API of the Month” is pacritinib, a selective oral Janus kinase inhibitor (JAK2) used for the treatment of adults with intermediate or high-risk myelofibrosis with a platelet count below 50 × 109/L. Pacritinib sold under the brand name Vonjo (CTI BioPharma) was approved on 28th of February 2022 with an oral, 200 mg dose, twice daily (1, 2).

ABOUT THE AUTHOR

Rodrigo Souza – Since I started my independent career, I have pursuit the development of new technologies to guide research by innovative ideas. We have been working at Federal University of Rio de Janeiro on the establishment of continuous-fl ow technology for active pharmaceutical ingredients (API) synthesis in Brazil, showing that is possible to reduce costs on production allowing the reduction of the final price of the medicine.

Login