Issue: January / February 2024

Nice drug if you can get it. Can’t get it if you try?* On the current scarcity of semaglutide (et alia).

5 March 2024 No Comments

The demand for incretin-based peptide drug substances such as semaglutide and tirzepatide to treat obesity has led to shortages of these drugs for diabetics and to plans for manufacturing these and other incretin peptides on an unprecedented scale in the future. Where solid phase synthesis (SPPS) is the chosen method of manufacture, the scale of these processes could possibly exhaust current SPPS reactor capacity. This article addresses the supply chain shortages of incretin-based drugs, the manufacturing process bottlenecks, drug costs, as well as the environmental burden, and suggests some solutions. It aims to create a discussion.

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High Potency Molecules: The Importance of Excellent Chemistry in their Successful Delivery

5 March 2024 No Comments

The high potency drug market is an exciting place and is likely only going to evolve. In this article, Rob Crook and Jean-Baptiste Vendeville discuss the current considerations needed when developing a synthesis for a HPAPI, as well as the challenges faced by these complex molecules, in particular ADCs. They will first highlight the development and growth of the market before a short review of the innovations being undertaken that can lead to lower costs and more efficient use of time and resources. Overall, they discuss how the requirement for excellent chemistry and innovation, along with exceptional route design, will be critical to the successful development of high potency molecules to secure their future potential as treatments.

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How the chemical sector is sparking a change in carbon accounting

4 March 2024 No Comments

Together for Sustainability (TfS) (1)– a global chemical industry initiative – and its 50 member companies are driving a shift in carbon accounting methodologies within the chemical industry. In its first ever White Paper (2), TfS identifies three areas for improvement: including biogenic carbon accounting, mass balance as a transitional mechanism and the use of recycled materials. These recommendations aim to incentivise the adoption of sustainable practices within the industry, and push for a recalibration of existing carbon accounting standards.

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