Issue: September / October 2024

Using the carbon footprint of your chemicals for strategic decision-making

2 October 2024 No Comments

This article aims to inform chemical and pharmaceutical companies on how to measure, reduce and communicate greenhouse gas emissions effectively. The chemical and pharmaceutical industries contribute significantly to global greenhouse gas emissions, and carbon footprinting and Net Zero aligned target setting is key to reducing emissions and costs. Gaining an in-depth understanding of your emissions hotspots directly from your company, and indirectly in the value chain, is critical to identify which areas to implement emissions reductions. Additionally, developing a strategy aligned with a Net Zero trajectory is crucial to communicate the impact of the companies work in a clear and transparent way.

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Distributors play a decisive role to improve sustainability in the supply chain for pharmaceutical companies

2 October 2024 No Comments

Working with distributors may not be the traditional sourcing route for pharmaceutical manufacturers but by working with those suppliers who have a commitment to compliance and transparency as well as an appetite for collaboration and innovation the pharma industry can leverage the portfolio and global reach of a chemical distributor to meet sustainability goals while protecting supply chain security.

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Engineering of enzyme biocatalysts with nano-sized polymers with upper critical solution temperature (UCST)

2 October 2024 No Comments

UCST-type polymer-immobilized enzymes use lower temperatures for biocatalyst separation than for homogeneously biocatalytic reactions, so as to ensure prevention of the immobilized enzymes from deactivation as well as achieving high biocatalytic performance. This article highlights the developments of nano-sized UCST-type polymer-immobilized enzymes in biocatalysis. The characteristics of the reported nano-sized UCST-type polymer-immobilized enzymes and their advantages and disadvantages in terms of biocatalytic performance, separation and reusability are summarized with an outlook on the engineering of enzymes with UCST-type polymers for biocatalysis.

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Novel purification strategies for lipid nanoparticles building blocks

2 October 2024 No Comments

Synthetic lipids have recently been used with great success in mRNA lipid nanoparticles (LNP) formulations, which has greatly increased their demand. Chromatography still remains a standard unit operation in the purification of these lipids. However, traditional normal phase chromatography often uses large amounts of toxic solvents, including chlorinated ones. In this article we present three case studies demonstrating alternative methods to achieve greater sustainability and/or reduce both environmental impact and operational cost. These methods include aqueous/non-aqueous reversed-phase chromatography (NARP) as well as super critical fluid chromatography (SFC).

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The power of patient engagement

2 October 2024 No Comments

80% of clinical trials are delayed due to recruitment problems. This is a well-known figure but despite its familiarity, it shouldn’t be normalised. It’s a dissatisfying number that calls for action to improve our work in clinical trials. Luckily, there’s a solution to this problem, and the even better news is that it will probably fix more than just the 80% issue. The aim of this article is to give a better understanding and overview of the challenges related to patient participation in clinical trials and providing actionable suggestions to activities that would solve these challenges and hopefully improve the drug development process all together.

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